Inpharmaceutical water systems, the TOC value (Total Organic Carbon) is usually determined online. Since bacteria also consist to a large extent of hydrocarbons, the question arises as to whether information about the microbial status of the water system can also be obtained by means of TOC monitoring.
在制药用水系统中，通常测定在线TOC值（总有机碳）。由于微生物也在很大程度上由碳氢化合物组成，因此出现了一个问题，即是否也可以通过TOC监测获得有关水系统微生物状态的信息。
Unfortunately, this is not possible. There are fast microbiological test procedures (without agar plates), also for pharmaceutical water systems. However, these usually work with other technologies, often by particle measurement and fluorescence. However, it is not possible to convert TOC values into bacterial counts. Nor is it possible to draw any conclusions about a possible biofilm in the system.
不幸的是，这是不可能的。快速微生物测试程序（不需要琼脂平板），也适用于制药用水系统。然而，这些通常与其他技术一起使用，通常是通过粒子测量和荧光。但是，不可能将TOC值转换为细菌计数。也不可能对系统中可能的生物膜得出任何结论。
Bacteria in water systems are typically only present to a minimal extent in the free-flowing medium water (aquatic). They rather collect in a biofilm that grows on surfacesin places in the system with less flow (stationary). In order to trigger a measured value in the TOC system, the germs would have to flow through the TOC. It is always possible that a part of a biofilm tears off and moves through the system for a short time. But even then it is statistically rather unlikely that it will flow straight and reproducibly through the measuring system at the time of measurement. Short-term peaks in TOC monitoring could therefore be caused by a biofilm, but they do not have to be. And to get close to the limit value of 500 ppb TOC, the water would have to be contaminated so heavily that this would probably already be recognisable by turbidity and odour.
水系统中的微生物通常只有在自由流动的介质水（水生）中才可以达到最低程度。它们聚集在生物膜中，生物膜生长在系统中流量较少（静止）的地方的表面上。为了在TOC系统中触发测量值，微生物必须流过TOC。生物膜的一部分总是有可能在短时间内撕裂并在系统中移动。但即便如此，从统计学上讲，它在测量时也不太可能直接且可重复地流过测量系统。因此，TOC监测中的短期峰值可能是由生物膜引起的，但并非总是如此。为了接近 500 ppb TOC 的限度值，水必须受到非常严重的污染，以至于这可能已经可以通过浊度和气味来识别。
On the other hand, a very low TOC value in the water system is a very good starting point to prevent the formation of a biofilm, as the organic material is the food for the biofilm-forming bacteria.
另一方面，水系统中非常低的TOC值是防止生物膜形成的良好起点，因为有机物是形成生物膜的微生物的食物。
